生物可吸收高分子支架的研究进展

冠脉介入支架治疗技术发展至今已有30余年,从裸金属支架发展到药物洗脱支架乃至今天新兴的生物可吸收支架,不断的推动着冠心病介入治疗向前进步。生物可吸收支架的理念是治疗后无异物留体内。总的来讲,支架开通并保持狭窄或堵塞血管畅通的使命在血管修复后即完成,此后最理想的状态便是支架也随之消失。生物可吸收高分子支架(Bioresorbable Polymeric Scaffold,BRPS)由于使用的材料不仅可以人为地设计和改性,而且是药物的良好载体,因此成为该领域研究的热点。本文从材料、结构设计、加工工艺等方面介绍了BRPS的研究进展,重点讨论了激光切割和3D打印制备BRPS的两种方法,以及BRPS的降解性能及要求,最后对BRPS面临的挑战及发展方向做了展望。

Review of Bioresorbable Polymeric Scaffold

For over 30 years interventional cardiovascular stenting has been developed from bare metal stents to drugeluting stents and even today's emerging bioabsorbahle stents,continuing to advance the technological therapy for the coronary heart disease.The idea of bioabsorbable stents is to leave no foreign body behind.In general,the stent functions to keep open a blocked artery and maintain the blood flow only until the vessel heals itself,so it would be ideal for the stent to disappear thereafter.Bioresorbable Polymeric Scaffold (BRPS) has gained a great deal of interest in the biomaterials field nowadays because it is made from a polymeric material which can be designed and modified for its intended use,while serving as a good drug carrier.This article discusses the roles of biomaterial,structure and processing in influencing the functions of a BRPS device,with an emphasis on the two manufacturing methods by laser cutting and 3D printing,as well as the degradation kinetics of BRPS.The challenges and trend of BRPS are also discussed.