仿贻贝粘性高分子的应用进展

海洋贻贝类生物的足丝分泌蛋白几乎能够在所有基底材料上实现高强度、高韧性的粘附,且不受水或者潮湿环境影响。这种环境友好、条件温和的高效生物粘附剂引起了研究人员的兴趣,尤其在粘附机理和应用前景方面更是研究人员关注的重点。大量研究表明,贻贝超强的粘附能力与其分泌的粘附蛋白中高含量的3,4-二羟基苯丙氨酸(多巴,DOPA)单元相关。受贻贝粘附蛋白的启发,人们研究发现,多巴胺(DA)分子具有与之相似的官能团,聚合后有相似分子结构,使用聚多巴胺替代聚多巴,可以在基体表面达到相似的粘附性能。本文简单介绍了仿贻贝粘性物质中的代表多巴胺自聚合形成聚多巴胺(PDA)与粘附机理,并重点介绍了近年来DOPA衍生物在表面改性、催化、生物防污及生物医学领域的应用和前景。

Progress in Application of Mussel-inspired Bio-mimic Polymers

Mussel adhesive protein can adhere to almost all kinds of surfaces with high strength,toughness,and resistance to water or moisture.This environmentally friendly,efficient adhesive in mild condition has aroused interests of researchers,especially in how it works and where it can be used.Most of the studieshave demonstrated that the strong adhesion ability of mussel is associated with a large amount of 3,4-dihydroxyphenyalanine(DOPA) in its adhesion protein.Inspired by the method that mussel adhesive proteins works,scientists found it possible to use DA instead of DOPA to achieve similar adhesion,because DA molecule has similar functional groups to DOPA as well as the similar molecular structure after polymerization.In this paper,the adhesive mechanism of mussel-inspired bio-mimic polymer,PDA,was introduced,and the applications of its derivatives PDA and in different fields,such as surface modification,catalyst,bioantifouling and biomedicine was reviewed.