普适型纸芯片的研究与应用

纸基分析芯片(纸芯片)具有成本低、便携化、操作和后处理简单无污染等优点,在临床诊断、食品质量控制和环境监测等领域有着广阔的应用前景。然而,由于难以制作性能优异的疏脂性屏障,使得纸芯片在涉及有机溶剂和表面活性剂的分析检测中,其发展受到了限制。针对当前纸芯片开发研究中存在的灵敏度较低、对有机溶剂和表面活性剂敏感等难点问题,研究人员在滤纸基底上制作出了性能优异的疏水隔离图案和高粘附疏水表面,并验证了所制备的纸芯片对涉及有机溶剂和表面活性剂的分析检测具有普适性。本文对此类普适型纸芯片的研究与应用进行评述。

Paper-based Analytical Devices with General Applicability

Paper-based analytical devices (PADs) show great prospects in clinical diagnosis,food quality control and environmental monitoring due to their intrinsic advantages such as low cost,portability,and easy operation and post-treatment without cross contamination.Nevertheless,present PADs often suffer from low detection sensitivity and are generally not applicable to analyses involving organic solvents or surfactant solutions due to the difficulties in fabricating lipophobic barriers.To address these issues,researchers fabricated high performance paper-based hydrophobic patterns and highly adhesive hydrophobic surfaces and demonstrated the fabricated PADs possess general applicability for assays involving organic solvents and surfactants.This review will introduce these reports on the study and applications of PADs with general applicability.