| 聚合物纳米光诊疗剂的制备与应用新进展 |
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| 引用本文： | 郭亮,葛介超. 聚合物纳米光诊疗剂的制备与应用新进展[J]. 影像科学与光化学, 2017, 35(4). DOI: 10.7517/j.issn.1674-0475.2017.04.008 |
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| 作者姓名： | 郭亮 葛介超 |
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| 作者单位： | 中国科学院理化技术研究所光化学转换与功能材料重点实验室,北京,100190 |
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| 基金项目： | 国家自然科学基金，中国科学院战略性先导科技专项B类 |
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| 摘 要： | 共轭聚合物纳米颗粒是由π-共轭有机聚合物组成的尺寸在1~100nm范围内的新型有机纳米材料。与传统的有机小分子、半导体量子点和无机纳米材料相比,聚合物纳米颗粒具有光学性质特殊、结构多样、表面易修饰和生物相容性好等优点,因而被广泛应用于生物成像、传感与检测、载药和治疗等领域。本文主要围绕聚合物纳米颗粒的制备方法、性质结构和生物相容性等方面,重点介绍了聚合物纳米颗粒作为光诊疗剂在荧光成像、光声成像,以及光动力和光热治疗领域的研究进展,并对聚合物纳米颗粒的发展前景和未来面临的挑战进行了探讨。
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| 关 键 词： | 聚合物纳米颗粒 光诊疗 荧光成像 光声成像 光动力治疗 光热治疗 |
New Progress Design and Synthesis of Versatile Polymer Nanoparticles as Phototheranostics for Cancer |
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| GUO Liang,GE Jiechao. New Progress Design and Synthesis of Versatile Polymer Nanoparticles as Phototheranostics for Cancer[J]. Imaging Science and Photochemistry, 2017, 35(4). DOI: 10.7517/j.issn.1674-0475.2017.04.008 |
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| Authors: | GUO Liang GE Jiechao |
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| Abstract: | Conjugated polymer nanoparticles (PNPs),which consist of π-conjugated organic polymers,are novel organic nanomaterials with the size in the range of 1-100 nm.Compared with the traditional organic small molecules,semiconductor quantum dots and inorganic nanomaterials,the PNPs show great potential applications in biological imaging,sensing and detection,drug delivery and theranostic,due to its advantages of special optical properties,diverse structure,easy surface modification and good biocompatibility.In this paper,we present a review of current development in PNPs,including their preparation,properties,and biocompatibility.Significantly,we summarized the new progress in preparation of versatile PNPs as phototheranostics for cancer,the problems needed to solve in future. |
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| Keywords: | polymer nanoparticle phototheranostics fluorescence imaging photoacoustic imaging photodynamic therapy photothermal therapy |
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