3D打印生物医用材料研究进展

3D打印(亦称增材制造)技术因其独特的材料成型优势,在组织工程、航空航天、汽车制造、以及电子工业等众多领域显示出巨大的应用潜力。然而,在实际生物医学应用中,3D打印生物器件和组织器官除了要求具有复杂的结构和优异的生物学性能外,其打印结构的表面性质也需满足某些特定的要求,如3D打印组织骨架和器官必须具有生物相容性、抗菌性及细胞粘附性等。因此,将3D打印与传统表面修饰技术相结合,在不改变材料三维结构的基础上调控其表面生物化学性质,从而赋予3D打印生物骨架器官多功能化,可实现更为广泛的应用。本文以3D打印生物骨架及器官的表面修饰为主要内容对就近年来3D打印生物医用材料的最新研究进展进行了综述。

A Review: Surface Modification of 3D Printing Complex Architectures

3D printing,also named as Additive Manufacturing,is attracting increasing attentions from tissue engineering,aerospace engineering,automotive industry and electronics,due to its advantages of free form design and manufacturing.Besides the complex structures and excellent biomedical properties,surface performances of 3D printing skeleton and organs are also crucial for practical applications,for example,biocompatible,antibacterial and cell adhesion properties are necessary to 3D printed tissue scaffolds and organs.Therefore,combining 3D printing technology with traditional surface modifications is significant for expanding 3D printing's applications.Multifunctional 3D printed skeleton and organs can be offered by post surface biochemistry modification of the skeleton and organs with retaining their bulk properties,and a more splendid application can be expected.In this review,we summarized the recent progress in the 3D printing biomedical materials based on the surface modification of 3D printed skeleton and organs.