Encapsulation of phthalocyanine supramolecular stacks into virus-like particles |
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| Authors: | Brasch Melanie de la Escosura Andrés Ma Yujie Uetrecht Charlotte Heck Albert J R Torres Tomás Cornelissen Jeroen J L M |
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| Institution: | Laboratory for Biomolecular Nanotechnology, MESA+ Institute, University of Twente, P.O. Box 207, 7500 AE Enschede, The Netherlands. |
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| Abstract: | We report herein the encapsulation of a water-soluble phthalocyanine (Pc) into virus-like particles (VLPs) of two different sizes, depending on the conditions. At neutral pH, the cooperative encapsulation/templated assembly of the particles induces the formation of Pc stacks instead of Pc dimers, due to an increased confinement concentration. The Pc-containing VLPs may potentially be used as photosensitizer/vehicle systems for biomedical applications such as photodynamic therapy. |
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