Synthesis and QSAR studies on thiazolidinones as anti-HIV agents |
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| Authors: | Rawal Ravindra K Solomon V Raja Prabhakar Yenamandra S Katti S B De Clercq E |
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| Institution: | Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India. |
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| Abstract: | Selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204 microM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity. |
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