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Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeriavaccine in the induction of immune responses against HIV
Authors:James B Whitney  Saied Mirshahidi  So-Yon Lim  Lauren Goins  Chris C Ibegbu  Daniel C Anderson  Richard B Raybourne  Fred R Frankel  Judy Lieberman  Ruth M Ruprecht
Affiliation:(1) Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, 02115 Boston, MA, USA;(2) Harvard Medical School, 02115 Boston, MA, USA;(3) Loma Linda University Cancer Center, 92354 Loma Linda, CA, USA;(4) Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 02115 Boston, MA, USA;(5) Division of Research Resources and Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, 30329 Atlanta, GA, USA;(6) Immunobiology Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 20708 Laurel, MD, USA;(7) Department of Microbiology, University of Pennsylvania, 19104 Philadelphia, PA, USA;(8) Department of Pediatrics, The Immune Disease Institute and Program in Cellular and Molecular Medicine Children’s Hospital Boston, 02115 New York, MA, USA
Abstract:

Background  

We have evaluated an attenuated Listeria monocytogenes (Lm) candidate vaccine vector in nonhuman primates using a delivery regimen relying solely on oral vaccination. We sought to determine the impact of prior Lm vector exposure on the development of new immune responses against HIV antigens.
Keywords:
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