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Tandem reduction + cyclization of ortho-substituted cinnamic esters |
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| Authors: | Daiane Cristina SassEmílio Carlos de Lucca Jr Jader da Silva BarbosaKleber Thiago de Oliveira Mauricio Gomes Constantino |
| Institution: | Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida dos Bandeirantes, 3900, 14040-901 Ribeirão Preto, SP, Brazil |
| Abstract: | Conjugate reduction of ortho-substituted cinnamic esters by Stryker’s reagent to form copper enolates, followed by intramolecular aldol-type cyclization, successfully generated indane and tetralin rings in one pot efficiently. This tandem reaction is generally diastereoselective and provides good yields. |
| Keywords: | Tandem reduction + cyclization Aldol-type cyclization Stryker&rsquo s reagent Indanes Tetralins |
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