Synthesis of the apoptosis inducing agent apoptolidin. Assembly of the C(16)-C(28) fragment |
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| Authors: | Sulikowski G A Lee W M Jin B Wu B |
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| Affiliation: | Department of Chemistry, Texas A&M University, College Station, Texas 77842-3012, USA. sulikowski@mail.chem.tamu.edu |
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| Abstract: | [reaction--see text] A stereoselective synthesis of the C(16)-C(28) fragment of the apoptosis inducing agent apoptolidin is described. Key steps include two propionate aldol reactions and a stereoselective Mukaiyama aldol addition of enolsilane 19 to beta-methoxy aldehyde 4. |
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