Toward catalytically active oligonucleotides: synthesis of a flavin nucleotide and its incorporation into DNA |
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Authors: | Schwögler A Carell T |
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Affiliation: | Department of Chemistry, Philipps-University Marburg, Germany. |
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Abstract: | [reaction--see text] The synthesis of a vitamin B(2)-derived flavin-nucleotide is described. A combined H-phosphonate/phosphoramidite protocol was developed for the first incorporation of flavin coenzymes into a DNA stack. The coenzyme-DNA is predicted to have novel biosensing and catalytic properties. |
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