Traceable platinum(II) complexes with alkylene diamine-derived ligands: synthesis,characterization and in vitro studies |
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| Authors: | Till Walther Renate Herzog Milena R Kalu?erovi? Christoph Wagner Harry Schmidt |
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| Institution: | 1. Institute of Chemistry, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany;2. Department of Oral, Maxillary, Facial and Reconstructive Plastic Surgery, University Hospital of Leipzig, Leipzig, Germany |
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| Abstract: | Diiodido- (6a/6b) and dichloridoplatinum(II) complexes (7a/7b) with fluorescent ligands 2-(2-aminoethyl)amino]ethyl-2-(methylamino)benzoate (5a) and 2-amino-1-(aminoethyl)ethyl-2-(methylamino)benzoate (5b) were prepared and characterized by elemental analysis, ESI-MS analysis, fluorescence spectrometry, as well as 1H, 13C, and 195Pt NMR spectroscopy. All compounds have been tested against A2780 ovarian cancer, A549 lung carcinoma, and HT-29 colon cancer cell lines using sulforhodamine-B assay. The activity increased from ligand precursors, diiodido- to dichloridoplatinum(II) complexes, except against HT-29 cell line where diiodido and dichlorido expressed similar activity. These compounds enter the tumor cells and emit a bright fluorescence at ca. 470 nm, mainly targeting nuclei. |
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| Keywords: | Cisplatin platinum(II) complexes cytotoxicity fluorescence |
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