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The enantioselective total synthesis of a beta-carboline alkaloid, (S)-(-)-dichotomine C
Authors:Omura Kana  Choshi Tominari  Watanabe Shiroh  Satoh Yuhsuke  Nobuhiro Junko  Hibino Satoshi
Institution:Graduate School of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima, Japan.
Abstract:The first enantioselective synthesis of a beta-carboline alkaloid, dichotomine C, possessing antiallergic effects, was achieved by constructing a beta-carboline framework based on the microwave-assisted thermal electrocyclic reaction of a 1-azahexatriene system, followed by the Sharpless asymmetric dihydroxylation.
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