Domino Reactions with Fluorinated Five-membered Heterocycles – Syntheses of Trifluoromethyl Substituted Butenolides and γ-Ketoacids |
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Authors: | Klaus Burger Lothar Hennig Annett Fuchs Dieter Greif Jan Spengler and Fernando Albericio |
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Institution: | (1) Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany |
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Abstract: | A new approach to trifluoromethyl substituted butenolides and their thioanalogues is described starting from 2-fluoro-3-trifluoromethylfurans
and -thiophenes, respectively. The reaction sequence includes three steps – nucleophilic displacement reaction, Claisen, and finally Cope rearrangement – which can be run as domino reaction. A modification of the domino reaction (transesterification instead of
Cope rearrangement) provides a concise access to α-trifluoromethyl-γ-ketoacids. |
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