Conformational exchange in pimonidazole--a hypoxia marker |
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| Authors: | Gabellieri Cristina Eykyn Thomas R Leach Martin O |
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| Institution: | Cancer Research UK Clinical Magnetic Resonance Research Group, The Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom, UK. |
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| Abstract: | Pimonidazole is one of a series of nitroimidazole compounds that is widely used as a marker for qualitative and quantitative assessment of tumour hypoxia. We have observed a novel dynamic conformational exchange process in this molecule in aqueous solution. By a combination of 1H, 13C, two-dimensional 1H-1H EXchange SpectroscopY (EXSY) and spectral simulation, we unambiguously attribute the conformational exchange process to flipping of the six-membered heterocyclic ring. |
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| Keywords: | NMR 1H 13C exchange pimonidazole hypoxia |
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