Diastereoselective total synthesis of isocarbacyclin from L-ascorbic acid |
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Authors: | Ishikawa Teruhiko Ishii Hirokazu Shimizu Kazuo Nakao Hiroe Urano Jin Kudo Takayuki Saito Seiki |
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Institution: | School of Education, and Department of Bioscience and Biotechnology, School of Engineering, Okayama University, Tsushima, Okayama, Japan. |
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Abstract: | Diastereoselective total synthesis of isocarbacyclin, which features a fused bicyclic key intermediate available from l-ascorbic acid, is described. The key intermediate was prepared in multigram quantities by the Pauson-Khand reaction of l-ascorbic acid-based (R)-4,4-diallyl-2,2-dimethyl-5-(trimethylsilyl)ethynyl-1,3-dioxolane (3), discriminating diastereotopic groups and faces of the geminal allyl substituents. |
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