Highly effective transition structure designed catalyst for the enantio- and position-selective dihydroxylation of polyisoprenoids |
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| Authors: | Corey E J Zhang J |
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| Institution: | Department of Chemistry and Chemical Biology Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. corey@chemistry.harvard.edu |
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| Abstract: | structure: see text] The chiral monocinchona derivative shown, synthesized in one step from two efficiently prepared chiral building blocks, was designed under mechanistic guidance as a catalyst for the enantio- and position-selective dihydroxylation of the terminal isopropylidene group of polyisoprenoids. Its efficacy as a synthetic reagent for this purpose was demonstrated for several different substrates. |
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