An orally administered microcapsule system for treating chronic renal failure patients |
| |
Authors: | D L Gardner C M Kjellstrand C R Hassler D J Fink D C Emmerling |
| |
Institution: | (1) Battelle-Columbus Laboratories, Columbus, Ohio;(2) Hennepin County Medical Center, Minneapolis, Minnesota |
| |
Abstract: | Ingestible adsorbents for the removal of uremic metabolites are being investigated as adjunctive therapy in the treatment
of chronic uremia. In particular, a microcapsule product containing urease and zirconium phosphate (UZP) has been investigated
for removing urea. A dog model, simulating chronic uremia, was developed to investigate: (1) the concentration of various
nitrogenous metabolites (urea, creatinine, and uric acid) in the GI tract, (2) flux rates of H2O and various nitrogenous metabolites in the GI tract, and (3) the efficacy of the microcapsule product. The results of these
perfusion studies suggest that urea and creatinine can be removed from the GI tract via ingestible adsorbents. In addition,
the model may be useful in investigating suspect uremic toxins, e.g., guanidinosuccinic acid (GSA). The reduction of blood
urea nitrogen levels in the dog model when the animal was fed the microcapsule product was limited by the capacity of the
zirconium phosphate to bind ammonium ion. Preliminary clinical studies with the microcapsule product indicate that it may
be of potential adjunctive therapy in patients suffering from chronic renal failure. |
| |
Keywords: | Animal model of chronic renal failure adsorbents in uremia microcapsules for the treatment of chronic renal failure GI tract and microcapsules nitrogenous metabolites and microcapsules flux rate and microcapsules uremia treatment with microcapsules |
本文献已被 SpringerLink 等数据库收录! |
|