| Regioselective etherification of 1,2-O-isopropylidene-4,6-di-O-benzyl myo-inositol |
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| 作者姓名： | YUAN Cheng-Ye ZHAI Hai-Xiao LI Shu-SenShanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai S China |
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| 作者单位： | YUAN，Cheng-Ye ZHAI，Hai-Xiao LI，Shu-SenShanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 20003S，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China. |
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| 摘 要： | During the etherification of 1,2-O-isopropylidene-4,6-di-O-benzyl myo-inositol, the specific regioselectivity on 3- or 5-hydroxyl group was showed to be determined by the nature of the O-alkylating agents used. As demonstrated by MM and MNDO calculation, the regioselectivity of the reaction mentioned can be rationalized by steric and/or electronic effect.
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Regioselective etherification of 1,2-O-isopropylidene-4,6-di-O-benzyl myo-inositol |
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| YUAN,Cheng-Ye ZHAI,Hai-Xiao LI,Shu-SenShanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai S,China.Regioselective etherification of 1,2-O-isopropylidene-4,6-di-O-benzyl myo-inositol[J].Chinese Journal of Chemistry,1996(3). |
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| Authors: | YUAN Cheng-Ye ZHAI Hai-Xiao LI Shu-Sen |
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| Institution: | YUAN,Cheng-Ye ZHAI,Hai-Xiao LI,Shu-SenShanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 20003S,China |
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| Abstract: | During the etherification of 1,2-O-isopropylidene-4,6-di-O-benzyl myo-inositol, the specific regioselectivity on 3- or 5-hydroxyl group was showed to be determined by the nature of the O-alkylating agents used. As demonstrated by MM and MNDO calculation, the regioselectivity of the reaction mentioned can be rationalized by steric and/or electronic effect. |
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| Keywords: | Regioselective etherification myo-inositol MM and MNDO calculation |
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