Separation of amino acid enantiomers VIA chiral derivatization and non-chiral gas chromatography |
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Authors: | Bertrand Marylène Chabin Annie Brack André Westall Frances |
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Institution: | Centre de Biophysique Moléculaire, CNRS, rue Charles Sadron, 45071 Orléans Cedex 2, France. bertrand@cnrs-orleans.fr |
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Abstract: | Two GC-MS methods for the enantioselective separation of the 20 proteinogenic amino acids are compared. Ethyl chloroformate and 2-chloropropanol were used to derivatize amino acid enantiomers. The diastereomers formed were separated on a non-chiral column by capillary gas chromatography. The separation performances were compared to those obtained when using non-chiral derivatization on a chiral column. |
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