Vapor deposition of intact polyethylene glycol thin films |
| |
| Authors: | DM Bubb BR Ringeisen JH Callahan M Galicia A Vertes JS Horwitz RA McGill EJ Houser PK Wu A Piqué DB Chrisey |
| |
| Institution: | (1) Naval Research Laboratory, Surface Modification Branch, Code 6370, 4555 Overlook Ave., SW, Washington, D.C. 20375, USA, US;(2) Naval Research Laboratory, Chemical Dynamics and Diagnostics Branch, Code 6115, 4555 Overlook Ave., SW, Washington, D.C. 20375, USA, US;(3) Department of Chemistry, George Washington University, Washington, D.C. 20001, USA, US |
| |
| Abstract: | Thin films of polyethylene glycol (PEG) of average molecular weight, 1400 amu, were deposited by both matrix-assisted pulsed
laser evaporation (MAPLE) and pulsed laser deposition (PLD). The deposition was carried out in vacuum (∼10-6 Torr) with an ArF (λ=193 nm) laser at a fluence between 150 and 300 mJ/cm2. Films were deposited on NaCl plates, Si(111) wafers, and glass slides. The physiochemical properties of the films are compared
via Fourier transform infrared spectroscopy (FTIR), electrospray ionization (ESI) mass spectrometry, and matrix-assisted laser
desorption and ionization (MALDI) time-of-flight mass spectrometry. The results show that the MAPLE films nearly identically
resemble the starting material, whereas the PLD films do not. These results are discussed within the context of biomedical
applications such as drug delivery coatings and in vivo applications where there is a need for transfer of polymeric coatings
of PEG without significant chemical modification.
Received: 2 March 2001 / Accepted: 5 March 2001 / Published online: 23 May 2001 |
| |
| Keywords: | PACS: 61 41 +e 81 05 Lg 81 15 Fg |
| 本文献已被 SpringerLink 等数据库收录！ |
|
