Facile Fabrication of Dendritic Mesoporous SiO2@CdTe@SiO2 Fluorescent Nanoparticles for Bioimaging |
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| Authors: | Shaohua Zhang Ling Wen Jianping Yang Jianfeng Zeng Qiao Sun Zhen Li Dongyuan Zhao Shixue Dou |
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| Institution: | 1. Center for Molecular Imaging and Nuclear Medicine, School of Radiation Medicine and Radiation Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation, Medicine of Jiangsu Higher Education Institutions, Suzhou, China;2. Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, Wollongong, NSW, Australia;3. Laboratory of Advanced Materials, Department of Chemistry, Fudan University, Shanghai, China |
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| Abstract: | A seeded watermelon‐like mesoporous nanostructure (mSiO2@CdTe@SiO2, mSQS) composed of a novel dendritic mesoporous silica core, fluorescent CdTe quantum dots (QDs), and a protective solid silica shell is successfully fabricated by loading QDs into dendritic mesoporous silica nanoparticles through electrostatic interaction, and then coating with a solid silica shell by the modified Stöber method. The shell thickness of mSQS can be tuned from 0 to 32 nm as desired by controlling the reaction parameters, including the amount of silica precursor, tetraethyl orthosilicate, that is introduced, the solvent ratio (H2O:ethanol), and the amount of catalyst (NH3?H2O). These fluorescent mSiO2@QDs@SiO2 nanoparticles possess excellent stability and thickness‐dependent cytotoxicity, and are successfully applied to bioimaging. |
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| Keywords: | dendritic mesoporous silica fluorescent imaging quantum dots silica coating |
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