| Synthesis of CMC-Multipeptide Conjugate |
| |
| 摘 要： | AlthoughbioactivePeptidesplayessentialpl~nacologicalroles,manyofUlemarelimitedintheiruseastrigsduetotheirrapidclearancefromtilebodyandlowstabilitytoprotCase.Besidesthemodificationoftilepeptidebackbone,suchaspseudopeptides,Peptides,andPeptide-nucleicacidetNA),covalentbondingpeptidewigalsomemolecules,suchasbranched-chainPOlrpeptidepeCP)andpolyethyleneglycol(PEG)',isanotheraPProachtoelthancePephdebioavailability.ThemeritofaPephde-POlymerconjugateiswithoutmutationinPeptidebackbonewhilegain…
|
Synthesis of CMC-Multipeptide Conjugate |
| |
| Abstract: | The synthesis of carboxymethyl cellulose (CMC)-multipeptide conjugate is reported in the present paper. This new type of pephde-polymer surrogate possesses some merits, such as ease of synthesis, high density of peptide, and the possibility of increased bioavailability, and seems to have promising uses in drug development. |
| |
| Keywords: | peptide carboxymethyl cellulose conjugate polymer ligation |
|
|
