| Synthesis and Structural Features of 3,5-Dihydroxy N′-(3-nitrobenzylidene) Benzohydrazide and Its Effect on the Intestinal Smooth Muscle |
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| 作者姓名： | ARCHANA Bajracharya WANG Li YE Dong-Mei CHEN Da-Peng DIAO Yun-Peng LIN Yuan |
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| 作者单位： | Department of Pharmacology,Dalian Medical University,Dalian 116044,China |
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| 基金项目： | This study was supported by the National Natural Science Foundation of China （No. 30772601 ） |
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| 摘 要： | A new compound,3,5-dihydroxy-N-(3-nitrobenzylidene)benzohydrazide (DNBB) methanol solvate,was synthesized and characterized by single-crystal X-ray diffraction.DNBB crystallizes in a monoclinic system,space group P2 1/c with a=8.387(4),b=23.237(10),c=9.133(3),β=122.10(3)o,Z=4,V=1507.8(12) 3,D c=1.464 g/cm 3,F(000)=696.0,μ=0.116 mm-1,the final R=0.0480 and wR=0.1294.DNBB exhibited low toxicity on Caco-2 cell culture and produced significant inhibitory effect on the contraction of rat jejunal longitudinal smooth muscle (JLSM).The mechanism of DNBB on JLSM was correlated to the stimulation of α and β adrenergic receptors since α receptor antagonist phentolamine and β receptor antagonist propranolol abolished the inhibitory effects of DNBB on the contraction of JLSM,respectively.
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| 关 键 词： | Schiff base crystal structure intestinal smooth muscle adrenergic α and β receptors inhibitory effects |
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