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Simple and practical synthesis of pyrano- and furano[3,2-c]-quinoline derivatives under non-Lewis acid catalysis
Authors:Rui Huan Liua  Xin Yub  Liang Hua  Nie Fang Yua  a
Institution:School of Pharmaceutical Sciences, Central South University, Changsha 410013, China ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 51006, China
Abstract:One-pot synthesis of substituted pyrano- and furano3,2-c]quinoline derivatives from appropriately substituted anilines, substituted benzaldehydes and dienophiles via Povarov reaction catalyzed by HCl-ethanol were reported.Good to excellent yields with high diastereoselectivity were obtained in all entries tested.
Keywords:Non-Lewis acid  Catalysis  HCl-ethanol  Diastereoselectivity  Povarov reaction
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