Thermodynamic quantities for the oxidation of ranitidine by diperiodatocuprate(III) in aqueous alkaline medium |
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Authors: | T M Veeresh R K Patil Sharanappa T Nandibewoor |
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Institution: | (1) P.G. Department of Studies in Chemistry, Karnatak University, Dharwad, 580 003, India |
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Abstract: | The kinetics of oxidation of the anti-ulcer drug, ranitidine hydrochloride (RNH) by diperiodatocuprate(III) (DPC) in alkaline
medium was studied spectrophotometrically. The reaction exhibits 1:2 stoichiometry (ranitidine:DPC). The reaction is of first
order in DPC] and has less than unit order in RNH] and negative fractional order in alkali]. The involvement of free radicals
was observed in the reaction. The oxidation has been found to proceed via a DPC-ranitidine complex, which decomposes slowly
in a rate-determining step followed by other fast steps to give the products, which were identified as ranitidine sulfoxide
by spot test and spectroscopic studies.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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