Tumor-homing peptide-based NIR-II probes for targeted spontaneous breast tumor imaging |
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| Institution: | 1. Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;2. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Shenzhen Institute of Wuhan University, Shenzhen 518057, China;3. College of Science, Innovation Center for Traditional Tibetan Medicine Modernization and Quality Control, Medical College, Tibet University, Lasa 850000, China;4. Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou 341000, China;1. Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, Chemical Biology Center, College of Chemistry, Central China Normal University, Wuhan 430079, China;2. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China;3. Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China;1. Institut des Sciences Moléculaires (ISM, UMR CNRS 5255), Université de Bordeaux, 351 cours de la Libération, 33405 Talence, France;2. Laboratoire de l’Intégration du Matériau au Système (IMS, UMR CNRS 5218), Université de Bordeaux, ENSCBP, 16 Avenue Pey-Berland, 33607 Pessac Cedex, France;3. Ecole Nationale Supérieure de Chimie, Institut Charles Gerhardt, 8 rue de l’Ecole Normale, 34296 Montpellier cedex 05, France;1. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China;2. Medical College, Tibet University, Lasa 850000, China;1. State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China;2. Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong Special Administrative Region;3. Frontiers Science Center for Flexible Electronics (FSCFE), MIIT Key Laboratory of Flexible Electronics (KLoFE), Northwestern Polytechnical University, Xi''an 710072, China |
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| Abstract: | Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) is a promising modality for real-time imaging of cancer and image-guided surgery with superior in vivo optical properties. So far, very few NIR-II fluorophores have been reported for in vivo biomedical imaging of chemically-induced spontaneous breast carcinoma. Herein, a NIR-II fluorescent probe CH1055-F3 with the nucleolin-targeted tumor-homing peptide F3 was demonstrated to preferentially accumulate in 4T1 tumors. More importantly, CH1055-F3 exhibited specific NIR-II signals with high spatial and temporal resolution, strong tumor uptake, and remarkable NIR-II image-guided surgery in dimethylbenzanthracene (DMBA)-induced spontaneous breast tumor rats. This report presents the first tumor-homing peptide-based NIR-II probe to diagnose transplantable and spontaneous breast tumors by the active targeting. |
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| Keywords: | NIR-II imaging F3 peptide Image-guided surgery Spontaneous breast carcinoma NIR-II probes |
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