Catalytic addition of metallo-aldehyde enolates to ketones: a new C-C bond-forming hydrogenation |
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Authors: | Koech Phillip K Krische Michael J |
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Affiliation: | Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA. |
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Abstract: | The first catalytic cross-aldolization of metallo-aldehyde enolates with ketone acceptors is enabled via hydrogenation of keto-enals with cationic rhodium catalysts. These results, in conjunction with prior studies involving the catalytic hydrogen-mediated reductive coupling of enones, dienes, and diynes with carbonyl acceptors, support the feasibility of developing a broad new class of catalytic C-C bond formations based on the electrophilic trapping of hydrogenation intermediates. [reaction: see text] |
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