Antibacterial polymeric coatings grown by matrix assisted pulsed laser evaporation |
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Authors: | Irina Alexandra Paun Antoniu Moldovan Catalin Romeo Luculescu Maria Dinescu |
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Affiliation: | 1. National Institute for Laser, Plasma and Radiation Physics, 077125, Magurele, Bucharest, Romania 2. Faculty of Applied Sciences, University Politehnica of Bucharest, 060042, Bucharest, Romania
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Abstract: | We report on a simple and environmental friendly method to produce composite biocompatible antibacterial coatings consisting of silver nanoparticles (AgNPs, size 40 nm) combined with polymer blends (polyethylene glycol/poly(lactide-co-glycolide), PEG/PLGA blends). The PEG/PLGA&AgNPs coatings were produced by Matrix Assisted Pulsed Laser Evaporation, using a Nd:YAG laser with λ=266 nm. The AgNPs were deposited either on top of a PEG/PLGA layer (i.e., bilayered coating), or simultaneously with the polymers (i.e., blended coating). In both cases, chemical analysis indicated that the polymers preserved their integrity, with no evidence of chemical interaction with the AgNPs. Morphological investigations evidenced homogenous distribution of individual AgNPs on the surface of the coatings, with no signs of aggregation. The size of the AgNPs was ~40 nm, consistent with size of the as-received ones. The presence of AgNPs in the coatings was confirmed by the absorption band at ~420 nm and their stability was checked by monitoring this absorption versus time. After exposure to air, the AgNPs from the bilayered coating showed signs of oxidation. In the blended coating, the oxidation of the AgNPs was prevented by the neighboring polymer molecules. Finally, preliminary investigations confirmed the bacterial killing activity of the coatings against Escherichia coli. |
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