Synthesis of the fully functionalized ABCDE ring moiety of ciguatoxin |
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Authors: | Kobayashi Shoji Alizadeh Babak H Sasaki Shin-ya Oguri Hiroki Hirama Masahiro |
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Affiliation: | Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. |
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Abstract: | A fully functionalized ABCDE ring moiety of ciguatoxin (CTX), the major causative agent of ciguatera poisoning, was synthesized for the first time. The present strategy involves the efficient installation of the C5-dihydroxybutenyl substituent and construction of the tetrahydrooxepin E ring using a novel alpha-chlorosulfide synthon. [structure: see text] |
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