Synthesis of a macrobicycle incorporating the tris(pyrazolyl)methane ligand |
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Authors: | Wang Leyong Chambron Jean-Claude |
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Institution: | Université de Bourgogne, Laboratoire d'Ingénierie Moléculaire pour la Séparation et les Applications des Gaz (CNRS, UMR 5633), 6 Boulevard Gabriel, 21100 Dijon, France. |
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Abstract: | Steric crowding of the 3-position of tris(pyrazolyl)borate and -methane ligands has produced tetrahedral metal complexes with controlled reactivity. As an alternative, we propose to incorporate the tris(pyrazolyl)methane chelate in a macrobicyclic structure in order to create a cavity with well-defined dimensions and shape. Acid-catalyzed equilibration of excess of the new pyrazole 3-(1H-pyrazol-3-yl)benzenemethanethiol acetate with HC(3,5-Me(2)pz)(3) followed by hydrolysis affords a functionalized tris(pyrazolyl)methane, which reacts with 1,3,5-tris(bromomethyl)benzene in K(2)CO(3)/DMF to give the title compound. structure: see text] |
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