Iron-facilitated direct oxidative C-H transformation of allylarenes or alkenes to alkenyl nitriles |
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Authors: | Qin Chong Jiao Ning |
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Institution: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China. |
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Abstract: | This paper describes the first direct approach to alkenyl nitriles from allylarenes or alkenes facilitated by an inexpensive homogeneous iron catalyst. Three C-H bond cleavages occur under the mild conditions during this process. Mechanistic studies indicate that the cleavage of the allyl C(sp(3))-H bond is involved in the rate-determining step. This observation may provide an opportunity to achieve C(sp(3))-H functionalization catalyzed by an iron catalyst. |
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