| Novel dihydropyrazole derivatives linked with multi（hetero）aromatic ring： Synthesis and antibacterial activity |
| |
| 作者姓名： | Lin Shan Bai Yan Wang Xin Hua Liu Hai Liang Zhu Bao An Song |
| |
| 作者单位： | a Key Laboratory of Anhui Educational Department, Anhui University of Technology, Maanshan 243002, China;b State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China;c Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China |
| |
| 基金项目： | the opening foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University,(No.2008GDGP0105);;;supported by the Young College Teachers Research Projects of Anhui Province(No.2008JQ1030);;the Young College Teachers Research Projects of Anhui University of Technology(No.QZ200809). |
| |
| 摘 要： | Eight novel heterocycle-substituted dihydropyrazole derivatives were synthesized and characterized by ESI-MS,~1H NMR and ~(13)C NMR.All of the compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis, Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa.The results show that compounds 9b,9g and 9h displayed significant activity with MIC values in the range of 0.39-1.562μg/mL against B.subtilis.
|
| 关 键 词： | 衍生物 抗菌活性 合成 金黄色葡萄球菌 芳环 枯草芽孢杆菌 NMR谱 电喷雾质谱 |
| 收稿时间： | 10 October 2008 |
Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring:Synthesis and antibacterial activity |
| |
| Lin Shan Bai,Yan Wang,Xin Hua Liu,Hai Liang Zhu,Bao An Song.Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring:Synthesis and antibacterial activity[J].Chinese Chemical Letters,2009,20(4):427-430. |
| |
| Authors: | Lin Shan Baia Yan Wanga Xin Hua Liu Hai Liang Zhu Bao An Songc a Key Laboratory of Anhui Educational |
| |
| Institution: | a Key Laboratory of Anhui Educational Department, Anhui University of Technology, Maanshan 243002, China;b State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China;c Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China |
| |
| Abstract: | Eight novel heterocycle-substituted dihydropyrazole derivatives were synthesized and characterized by ESI-MS,1H NMR and 13C NMR.All of The compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis.Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa.The results shou that compounds 9b.9g and 9h displayed significant activity with MIC values in the range of 0.39-1.562 μg/mL against B.subtilis. |
| |
| Keywords: | Synthesis Multi(hetero)aromatic pyrazole Antibacterial activity |
| 本文献已被 CNKI 维普 万方数据 ScienceDirect 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
