<i>N</i>-Alkylation of diethyl acetamidomalonate: synthesis of constrained amino acid derivatives by ring-closing metathesis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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N-Alkylation of diethyl acetamidomalonate: synthesis of constrained amino acid derivatives by ring-closing metathesis

Authors:	Sambasivarao Kotha Kuldeep Singh

Institution:	^aDepartment of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400 076, India

Abstract:	An efficient method for N-alkylation of diethyl acetamidomalonate (DEAM) is reported. C-Alkenylation was achieved by treating the N-alkenylated DEAM with various electrophiles in the presence of Cs₂CO₃. RCM reactions of C- and N-alkenylated products gave cyclic amino acid derivatives in good yields.

Keywords:	Diethyl acetamidomalonate Regioselective N-alkylation Metathesis Constrained amino acid derivatives Heterocycles
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