Molecular modeling on the recognition of DNA sequence and conformational repair of sheared DNA by novel chiral metal complex D,L-[Co(phen)2hpip]3+ |
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Authors: | Wu Yanbo Zhang Cuiping and Yang Pin |
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Institution: | (1) Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, China |
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Abstract: | A study on the recognition of DNA sequence and conformational repair of sheared DNA by Novel Chiral Metal complex D,L-Co(phen)2hpip]3+ (phen=1,10 phenanthroline, hpip=2-2-hydroxyphenyl] imidazole 4,5-f]1,10] phenanthroline) is carried out with molecular
simulations. The results reveal that two isomers of the complex could both recognize the normal DNA in the minor groove orientation,
while recognize the sheared DNA in the major groove orientation and both isomers could convert the conformation of mismatched
bases from sheared form to parallel form. Further analysis shows that the steric details of complex’s intercalation to base
stack determine the results of recognition, which is induced by the steric collision among ancillary ligand phen, bases and
DNA backbone, and by the steric crowding occurring in the process of structural expansion of bases and DNA backbone. Detailed
analysis reveals that the conformational repair of mismatched bases relates not only to the steric interactions, but also
the π-π stack among normal bases, mismatched bases and hpip ligand. |
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Keywords: | mismatched DNA metal complex molecular modeling docking |
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