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Proposed performance qualification and calibration method for evaporative light scattering detectors
Authors:J. L. Sims
Affiliation:(1) Glaxo SmithKline Beecham Pharmaceuticals Research and Development, New Frontiers Science Park, CM19 5AW Harlow, Essex, UK
Abstract:Summary A method for the performance testing of Sedex 55 Evaporative Light Scattering Detectors (ELSD) has been developed as part of our regulatory compliance programme. The method uses a readily available chromatographic column, caffeine as the test probe and can be completed in less than one hour.
Keywords:Column liquid chromatography  Light scattering detection  Performance qualification
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