| 用中子活化分析法研究25种元素在人体肝脏亚细胞组分中的分布 |
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| 引用本文： | 陈春英,章佩群,卢向丽,侯小琳,柴之芳. 用中子活化分析法研究25种元素在人体肝脏亚细胞组分中的分布[J]. 分析化学, 1999, 27(4): 378-382 |
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| 作者姓名： | 陈春英 章佩群 卢向丽 侯小琳 柴之芳 |
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| 作者单位： | 中国科学院高能物理研究所核分析技术开放实验室,北京,100080 |
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| 基金项目： | 国家自然科学基金(29575214)，中国科学院院长基金 |
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| 摘 要： | 采用差速离心分离技术与中子活化分析法（ＮＡＡ）相结合的方法分析了人肝２５５中元素，并用标准参考物保证结果的准确性。分析结果表明，大多数元素在各亚细胞组分中并非均匀分布。Ａｓ、Ａｕ、Ｃｏ、Ｉ、Ｍｇ、Ｓｂ、Ｓｅ在细胞核和线粒体浓度最高。Ａｌ、Ｓｓ、Ａｕ、Ｂａ、Ｆｅ、Ｉ、Ｍｇ、Ｍｏ、Ｓｂ、Ｓｃ在细胞核和线粒体浓度最高。Ａｌ、Ａｓ、Ａｕ、Ｂａ、Ｆｅ、Ｉ、Ｌａ、Ｍｇ、Ｍｎ、Ｓｂ、Ｓｅ在胞液中深度最低，生物体
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| 关 键 词： | 人体肝脏 微量元素 亚细胞组分 中子活化分析 |
Subcellular Distribution of 25 Elements in the Human Liver by Neutron Activation Analysis |
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| Chen Chunying,Zhang Peiqun,Lu Xiangli,Hou Xiaolin,Chai Zhifang. Subcellular Distribution of 25 Elements in the Human Liver by Neutron Activation Analysis[J]. Chinese Journal of Analytical Chemistry, 1999, 27(4): 378-382 |
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| Authors: | Chen Chunying Zhang Peiqun Lu Xiangli Hou Xiaolin Chai Zhifang |
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| Abstract: | The distribution pattern of 25 elements in subcellular fractions of human liver was studied by differential centrifugation combined with neutron activation analysis. The analytical quality had been verified by the analysis of some standard reference materials. The highest concentrations of As, Au, I, Mg, Mo, Sb, Sc, Se were found in nuclei and mitochondria, whereas those of Br, Cu, Cl, K and Na in cytosol. The lowest concentrations of Al, As, Au, Ba, Fe, I, La, Mg, Mn, Sb, Se were found in cytosol. Interestingly, As was mainly present in the nuclear fraction and was two to four times than that in the other fractions, while La and Fe were enriched in the microsomal fraction. |
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| Keywords: | Human liver trace elements distribution pattern subcellular fractions neutron activation analysis |
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