Accelerator mass spectrometry (AMS) of the inhibitory effect of six dietary constituents on nicotine-hemoglobin adduction in mice |
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| Authors: | Y Cheng H F Wang H F Sun H L Li Y F Liu S X Peng K X Liu Z Y Guo |
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| Institution: | (1) Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China;(2) Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China;(3) Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China;(4) Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China;(5) Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China;(6) Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100871, P.R. China;(7) Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100871, P.R. China;(8) Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100871, P.R. China |
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| Abstract: | Summary Accelerator mass spectrometry (AMS) is an ultra-sensitive method to monitor and trace the environmental exposure levels of 14C-labeled molecules in vivo. Nicotine 3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco products, has proven to be a potential genotoxic compound. Using 14C-labeled nicotine and AMS, we have investigated the inhibitory effect of curcumin, garlic squeeze, grapeseed extract, tea polyphenols, vitamin C and vitamin E, respectively, on nicotine-hemoglobin (Hb) adduction in vivo. The results demonstrated that these dietary constituents induced remarkable decrease of nicotine-Hb adducts. The inhibitory fact may afford an important clue of the chemoprevention of the potential nicotine-induced carcinogenesis. |
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