Photocontrol of tyrosine phosphorylation in mammalian cells via genetic encoding of photocaged tyrosine |
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| Authors: | Arbely Eyal Torres-Kolbus Jessica Deiters Alexander Chin Jason W |
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| Affiliation: | Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom. |
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| Abstract: | We report the first site-specific genetic encoding of photocaged tyrosine into proteins in mammalian cells. By photocaging Tyr701 of STAT1 we demonstrate that it is possible to photocontrol tyrosine phosphorylation and signal transduction in mammalian cells. |
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