Synthesis and some transformations of N,2,2-trimethyltetrahydro-2H-pyran-4-amine |
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| Authors: | N. S. Arutyunyan R. L. Nazaryan L. A. Akopyan G. A. Panosyan G. A. Gevorgyan |
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| Affiliation: | 1.Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry,National Academy of Sciences of Armenia,Erevan,Armenia;2.Molecular Structure Research Center,National Academy of Sciences of Armenia,Erevan,Armenia |
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| Abstract: | Reaction of 2,2-dimethyltetrahydro-2H-pyran-4-one with aqueous methanamine, followed by reduction of the Schiff base thus obtained with sodium tetrahydridoborate gave N,2,2-trimethyltetrahydro-2H-pyran-4-amine which was subjected to cyanoethylation with acrylonitrile. The resulting 3-(2,2-dimethyltetrahydro-2H-pyran-4-ylmethylamino)propanenitrile was reduced with lithium tetrahydridoaluminate to N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-N-methylpropane-1,3-diamine, and some chemical transformations of the latter were studied. |
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