|
|||||
|
|
Pharmaceutical applications of photothermal beam deflection |
|
| Authors: | B. D. Hanh W. Faubel S. Heissler S. Wartewig R. H. Neubert |
| Affiliation: | (1) Department of Pharmacy, Institute of Pharmaceutics and Biopharmaceutics, Martin Luther University, Wolfgang Langenbeck Str. 4, Halle/Saale, D-06120, Germany;(2) Institute for Technical Chemistry, Department of Water and Geotechnology, Research Center Karlsruhe, P.O. Box 3640, Karlsruhe, D-76021, Germany;(3) Institute of Applied Dermatopharmacy, Martin Luther University, Wolfgang Langenbeck Str. 4, Halle/Saale, D-06120, Germany |
| Abstract: | We report the potential use of a noninvasive method of photothermal beam deflection (PBD) in pharmaceutical research exemplifying the determination of drug content in semisolid formulations and mapping the lateral drug diffusion into an artificial membrane. PBD exhibits a high sensitivity. The requirement of only minimal sample preparation makes this spectroscopic technique advantageous. PBD in conjunction with an appropriate scanner device and depth profiling is a promising technique for in vivo studies of three-dimensional drug diffusion into biological membranes. A short introduction to the basic principles of PBD is given. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |