A novel homoisocarbacyclin analog with potent and long-lasting activity. |
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| Authors: | M Shibasaki A Takahashi T Aoki H Sato S Yamada M Kudo K Kogi S Narita |
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| Institution: | Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. |
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| Abstract: | A synthesis of a novel and chemically stable homoisocarbacyclin analog, TY-11223 (3), has been accomplished. The analog (3), given intravenously or orally, showed potent and long-lasting activities in inhibiting platelet aggregation and, in addition, a good selectivity in biological activities. |
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