A modular, one-pot, four-component synthesis of polysubstituted 1,3-oxazolidines |
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| Authors: | Tejedor David Santos-Expósito Alicia González-Cruz David Marrero-Tellado José Juan García-Tellado Fernando |
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| Affiliation: | Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Islas Canarias, Spain. |
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| Abstract: | A modular, one-pot, two-step, four-component synthesis of polysubstituted 1,3-oxzolidines is described. The method comprises two linked domino processes: an organocatalyzed domino reaction of alkyl propiolate and an aliphatic aldehydes and a microwave-assisted amine addition cyclization domino process. An alternative modular, one-pot, three-step, four-component synthesis has also been developed by linking the organocatalyzed domino process to a sequential amine addition/Yb(OTf)(3)-catalyzed enamine cyclization reaction. |
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