Metalloantitubercular compounds Part 3: Synthesis,crystal structure,spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct |
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| Authors: | Dilip Kumar Saha Sommai Patitungkho Subhash Padhye Dileep N Deobagkar Aarti Ozarkar Mohan M Bhadbhade Rajesh G Gonnade |
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| Institution: | (1) Department of Chemistry, University of Pune, Pune, 411 007, India;(2) Department of Zoology, University of Pune, Pune, 411 007, India;(3) National Chemical Laboratory, Pashan, Pune, 411 008, India |
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| Abstract: | The X-ray crystal structures of two ciprofloxacin compounds, viz. Cu(cfH)2(Cl)2] · 2MeOH · 6H2O (2) and Cu(cfH)(phen)Cl]BF4 · 4H2O (3) are reported. Complex (2) has a distorted octahedral geometry, whereas for the nitrogen adduct (3) a distorted square–pyramidal geometry is seen. Significant enhancement in the antimycobacterial activity of the copper conjugates correlates with their copper redox couples (Cu2+ /Cu+) probably due to its relevance to intracellular accumulations and subsequent role in generating oxidative stress. |
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