Investigation of thermal behavior of enoxacin and its hydrochloride |
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Authors: | Shi Jingyan Wang Zhiyong Liu Yuwen Wang Cunxin |
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Institution: | (1) Department of Chemistry and Environment Engineering, Wuhan Bioengineering Institute, Wuhan, 430415, Hubei, China;(2) College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, Hubei, China |
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Abstract: | The thermal behaviors of enoxacin and its hydrochloride under inert conditions were investigated by TG, FTIR, and TG/DSC-FTIR.
The results indicated that the thermal behavior of enoxacin can be divided into three stages, while its hydrochloride consisted
of four stages. The main difference lay in the sequence of decarboxylation and decarbonylation. For the enoxacin, the decarboxylation
and decarbonylation occurred simultaneously, but for its hydrochloride, the two processes occurred in turn. The reason for
this was the existence of hydrochloric acid in enoxacin hydrochloride, which changed its intermolecular force. The thermal
analysis kinetic calculations of their first two stages were carried out, respectively. The apparent activation energy, pre-exponential
factor, and the most probable model function were obtained using the master plots method. The results indicated that all these
stages can be described by the model of nucleation and nucleus growing. |
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Keywords: | |
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