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Substituted cinnamides: Characterization of non-toxic inhibitors of alpha-synuclein aggregation

Institution:	1. Department of Biotechnology, M. V. Lomonosov Moscow State University, 119234 Moscow, Russian Federation;2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;3. National Research University Higher School of Economics (HSE University), 101000 Moscow, Russian Federation;4. A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, 119234 Moscow, Russian Federation;5. Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia;6. Institute of Biochemistry and Biophysics, University of Tehran, 1417614335 Tehran, Iran;7. Institute of Molecular Medicine, I. M. Sechenov First Moscow State Medical University, 119991 Moscow, Russian Federation;1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russian Federation;2. D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation;3. M. M. Shemyakin–Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russian Federation;4. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. N. S. Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 117393 Moscow, Russian Federation;3. National Research Center ‘Kurchatov Institute’, 123182 Moscow, Russian Federation;1. A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991 Moscow, Russian Federation;2. National Research University Higher School of Economics (HSE University), 101000 Moscow, Russian Federation;3. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;4. G. V. Plekhanov Russian University of Economics, 117997 Moscow, Russian Federation;5. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation

Abstract:	Four substituted cinnamides were studied as potential inhibitors of alpha-synuclein aggregation. (E)-3-3-(Benzod]1,3]dioxol-5-yl)acrylamido]benzoic acid (SMB11) was shown to inhibit amyloid fibril formation of recombinant human alpha-synuclein according to Congo Red and partial proteolysis by proteinase K assays. This compound and its analog with 3-trifluoromethylphenyl substituent demonstrated no cytotoxicity on human neuroblastoma SH-SY5Y cells.

Keywords:	alpha-synuclein amyloid aggregation cinnamides surface docking Parkinson’s disease
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