CH-alkylation of furan derivatives under photoinduced Pd catalysis |
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| Institution: | 1. Platov South-Russian State Polytechnic University, 346428 Novocherkassk, Russian Federation;2. Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, 510640 Guangzhou, China;1. Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, 230026 Hefei, China;2. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;1. Department of Materials Science, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;1. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;2. N. N. Semenov Research Center for Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russian Federation;1. Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, Russian Federation;2. Siberian State Medical University, 634050 Tomsk, Russian Federation;3. National Research Tomsk Polytechnic University, 634050 Tomsk, Russian Federation;4. Scientific Center for Mental Health, 115522 Moscow, Russian Federation;5. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 634028 Tomsk, Russian Federation |
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| Abstract: | A new method for selective C(5)–H alkylation of 2-substituted furans with tertiary and secondary alkyl bromides under photoinduced by visible light (∼460 nm) palladium catalysis has been developed. The method is relied on the use of available Pd(PPh3)4 catalyst under mild conditions (30 ± 5 °C, K2CO3 as base), tolerates to various functional groups in furanic substrates and provides from good to excellent yields of alkylated products. |
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| Keywords: | furan CH-alkylation palladium photoinduced metal catalysis 2-hetarylfurans |
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