Synthesis and cytotoxicity studies of new 1,2,4-thiadiazole derivatives and their zinc complexes |
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| Institution: | 1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation;3. V. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 119334 Moscow, Russian Federation;4. N. I. Pirogov Russian National Research Medical University, 117997 Moscow, Russian Federation;1. Faculty of Chemistry, Tomsk State University, 634050 Tomsk, Russian Federation;2. Research Institute of Medical Genetics, 634050 Tomsk, Russian Federation;3. Siberian State Medical University, 634055 Tomsk, Russian Federation;4. Tomsk Polytechnic University, 634050 Tomsk, Russian Federation;1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russian Federation;3. Photochemistry Centre, FRC ‘Crystallography and Photonics’, Russian Academy of Sciences, 119421 Moscow, Russian Federation;1. National Research Center ‘Kurchatov Institute’, 123182 Moscow, Russian Federation;2. A. V. Shubnikov Institute of Crystallography, FSRC ‘Crystallography and Photonics’, Russian Academy of Sciences, 119333 Moscow, Russian Federation;3. A. S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russian Federation |
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| Abstract: | A new polyfunctional ligand of the thiadiazole family was synthesized. Cytotoxic properties with respect to leukemic cell lines, radiation stability, predicted permeability through the blood–brain barrier and cardiotoxicity of the new ligand and its precursor were determined. New zinc complexes with N-{2-5-(3-chloro-4-methylphenylamino)-1,2,4-thiadiazol-3-yl]-1-methylethyl}-N-(2,2,6,6-tetramethylpiperidin-4-yl)-amine as the ligand have been obtained. |
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| Keywords: | 5-anilino-1 2 4-thiadiazoles zinc complexes cardiotoxicity radiation stability cytotoxicity leukemic cell lines |
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