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Aza-Nazarov cyclization cascades |
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| Authors: | Sai Kiran Kumar Solingapuram O'Connor Matthew J Klumpp Douglas A |
| Affiliation: | Department of Chemistry, Northern Illinois University, DeKalb, IL 60115, United States |
| Abstract: | Benzamides with tethered acetal groups undergo reactions in CF3SO3H to give ring-fused isoindolinones by a cyclization cascade. The reaction initially forms an N-acyliminium ion which then gives the isoindolinone by the aza-Nazarov reaction. An unusual variant also cyclizes at the allylic position. |
| Keywords: | Heterocycles Aza-Nazarov Superacid N-Acyliminum ions Cyclization |
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