A new strategy for synthesizing the steroids with side chains from steroidal sapogenins: synthesis of the aglycone of OSW-1 by using the intact skeleton of diosgenin |
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| Authors: | Qi-hai Xu Xiao-wen Peng Wei-sheng Tian |
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| Institution: | aShanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China |
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| Abstract: | The protected aglycone of saponin OSW-1, a new antitumor natural product, was synthesized in 13 linear steps in 9.5% overall yield by utilizing the intact skeleton of diosgenin. This strategy demonstrated a higher efficiency than the routine synthesis of steroids with side chains. |
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| Keywords: | OSW-1 antitumor aglycone diosgenin steroids |
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